Isvara means God, Supreme Being, personal God, or special Self.
Isvara Pranidhana is the last of the niyamas in the Yoga Sutras. Pranidhana is to surrender. In this practice we trust that everything that is happening is happening under the guidance of a higher power.
To trust God, a Supreme Being, or special Self will mean that above all else we trust this higher power, meaning that we do not look to other things as higher than that. For example, we trust that people can make decisions for themselves, whether they are making the right decisions or not, and we should not interfere in the choices that they make.
Please consider this with regards to the current affairs. Can you think of a group of people that are certain that they know the truth? For example a group of people who insist they know the truth about science, and that only they know, and for that reason the other side of a debate must be silenced. If you trust that group of people, I hope you will come into an awareness that, what these people are doing is not science. What they are doing is stopping real science from happening. Science can be miraculous, like Isvara, and can save lives but not if it is hindered by censorship.
Here are the words of Dr. Richard Feynman, an American theoretical physicist, known for his work in the path integral formulation of quantum mechanics “I would rather have questions that can’t be answered than answers that can’t be questioned.”